首页  研究所概况  研究方向  人才队伍  科研成果  研究设施与仪器设备  开放与交流  人才招聘  联系我们 
代谢与精神神经疾病研究所

 首页 
 研究所概况 
 研究方向 
 人才队伍 
 科研成果 
 研究设施与仪器设备 
 开放与交流 
 人才招聘 
 联系我们 

科研动态
        ★★★
课题组在《Endocrinology》发表题为“Sex-specific and estrous cycle-dependent antidepressant-like effects and hippocampal Akt signaling of leptin”的文章。
作者: 文章来源: 点击数: 更新时间:2015-07-21
Endocrinology.  2015 Jul 16:EN20151029. [Epub ahead of print]

Sex-specific and estrous cycle-dependent antidepressant-like effects and hippocampal Akt signaling of leptin

Carrier N 1,   Wang X 1, 2,   Sun L 1, 2,   Lu XY 1.

Abstract

Sex differences in the incidence of depression and antidepressant treatment responses are well documented. Depression is twice as common in women as in men. Recent studies indicate that low levels of leptin, an adipocyte-derived hormone, are associated with increased symptoms of depression in women. Leptin has been shown to produce antidepressant-like effects in male rodents. In the present study, we examined sex differences and estrous cycle variations in antidepressant-like responses to leptin. Leptin administration significantly reduced immobility, a putative measure of behavioral despair, in the forced swim test in intact female mice in the proestrus phase but not diestrus phase of the estrous cycle. Moreover, leptin administration stimulated Akt phosphorylation in the hippocampus of female mice in proestrus but not diestrus, in correlation with its differential behavioral effects in these two phases of the cycle. Leptin-induced behavioral responses and stimulation of hippocampal Akt phosphorylation in female mice were abolished by ovariectomy (OVX). By contrast, the antidepressant-like effect of leptin in male mice was not affected by gonadectomy (castration). Pretreatment with 17β-estradiol restored sensitivity to the effects of leptin on behavior and hippocampal Akt phosphorylation in OVX female mice. These results suggest leptin regulates depression-like behavior hippocampal Akt signaling in a sex-specific and estrous cycle-dependent manner.

PMID:
26181103
[PubMed - as supplied by publisher]



责任编辑:daixie 
  • 上一篇新闻:实验室在《Molecular Psychiatry》发表题为“Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors”的文章.
  • 下一篇新闻: 本所在《Translational Psychiatry》发表题为“Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates”的文章
  • 【字体: 】【 加入收藏】【打印此文】【关闭窗口